Age Repair NanoSerum

Nano-Encapsulation Platform for Anti-Aging Actives

Vegalab’s Age Repair NanoSerum leverages the same cutting-edge nano-encapsulation technology to deliver its anti-aging actives deep into the dermis. Specifically, this serum uses LbL nanocapsules to carry rejuvenating molecules (like NAD⁺ and silk-derived proteins) past the stratum corneum. By programming the capsule layers to respond to skin’s internal environment (enzymes, pH), the actives are largely shielded until they reach targeted cells. This ensures ingredients such as NAD⁺ – usually with poor topical bioavailability – are released in situ where they can stimulate collagen and cell repair. The nano-delivery also allows inclusion of high concentrations of actives without surface irritation, because the payload isn’t dumped all at once on the skin. For example, the serum contains a notable dose of NAD⁺ and fibroin; with conventional formulas these might just sit on the epidermis or cause sensitivity, but Vegalab’s encapsulation drives them into dermal fibroblasts gradually. In essence, nano-encapsulation turns this serum into a “smart bomb” against skin aging – potent actives homing in on fibroblasts and basal cells to trigger regeneration, while bypassing the surface barrier. The result is accelerated collagen synthesis, elastin renewal, and cellular normalization that typical creams or serums (which mostly work on the upper epidermis) cannot match. This platform is the differentiator allowing Age Repair NanoSerum to legitimately claim “dermal revitalization” rather than just a temporary plumping or smoothing.

Key Active Ingredients & Benefits

NAD⁺ (Nicotinamide Adenine Dinucleotide) – As in the Hyaluronic serum, NAD⁺ is the linchpin molecule for youthful cell function. In the context of Age Repair, NAD⁺ works to restore and normalize cellular metabolism in aging skin. It fuels SIRT1 and PARP enzymes that repair DNA and maintain telomeres, thereby helping fibroblasts behave like younger cells. Topically applied NAD⁺ has been shown to protect skin cells from UV damage and oxidative stress, reducing the formation of wrinkles and photo-pigmentation. However, NAD⁺ on its own does not penetrate well – Age Repair NanoSerum’s encapsulation overcomes that. By delivering NAD⁺ into the dermis, this serum helps prevent collagen breakdown (by inhibiting NAD-consuming enzyme CD38 and boosting cellular NAD levels) and promotes new collagen production via fibroblast activation. The outcome is a slowing of visible skin aging: fine lines and wrinkles are minimized, and skin’s firmness is preserved. (In simpler terms for clients: NAD⁺ “recharges” the skin’s batteries, so cells act younger and keep the skin structure intact.)

Fibroin (Silk Protein) – A regenerative protein that directly targets the dermal matrix. Fibroin’s role here is to accelerate the skin’s natural healing and renewal processes. It remains stable in skin (resisting enzymatic breakdown) long enough to exert pro-healing effects. Fibroin has been found to stimulate production of type I and III collagen – essential for repairing thinning, aging skin – and to promote the migration and proliferation of fibroblasts in wounds. In Age Repair NanoSerum, fibroin essentially “coaches” sluggish aging fibroblasts to ramp up new collagen/elastin fibers. This helps fill in wrinkles and improve elasticity over time. Additionally, silk fibroin has anti-inflammatory properties; it can calm chronic subclinical inflammation in aged skin that leads to breakdown of tissue. By doing so, it not only repairs but protects the dermis from further collagen loss. The ingredient’s biocompatibility means it causes no adverse reactions and forms a supportive matrix within skin – think of it as providing a scaffolding upon which new youthful tissue can form.

Sericin (Silk Protein) – Though not explicitly listed in the shorter Age Repair product description on the site, sericin is a natural companion to fibroin in silk and is present in Vegalab’s silk complex. Sericin enhances the skin barrier and moisture while fibroin works deeper. It complements Age Repair by ensuring aging skin (often prone to dryness) retains hydration and pliability – important, because a hydrated skin is less prone to wrinkle formation. Sericin also helps maintain skin’s surface smoothness and radiance; by reducing roughness and irritation, it gives an immediate perception of improved texture, even as the deeper actives work on long-term structure. Moreover, sericin’s antioxidant amino acids help neutralize free radicals on the skin surface, protecting against environmental aging factors.

Centella Asiatica Extract – Included for its collagen-stimulating and soothing effects. Centella (rich in madecassoside) is well-known to promote type I collagen synthesis and aid in repairing photo-damaged skin. In Age Repair NanoSerum, it provides an herbal boost to the high-tech actives: helping to firm skin and reduce fine lines (in synergy with fibroin) and calm any irritation (NAD⁺ and rapid cell turnover can sometimes cause transient redness; Centella counters that). It essentially ensures that the intense renewal processes happening under the skin result in a smooth, calm complexion on the surface.

(These key ingredients are delivered in a lightweight yet nourishing base with humectants and lipids to support the skin barrier. The formula is free of fragrances or harsh retinoids, focusing instead on biologically harmonizing ingredients that rebuild skin from within.)

Scientific Studies Supporting Ingredient Efficacy

A selection of 30 scientific studies is provided to validate the anti-aging ingredients in Age Repair NanoSerum and their mechanisms:

·       NAD⁺ support for anti-aging biomarkers (in vitro human dermal fibroblast study; exogenous NAD⁺ and a phytochemical complex evaluated for effects on aging-related markers). — https://pmc.ncbi.nlm.nih.gov/articles/PMC11544843/

·       Review: silk sericin and fibroin materials for skin repair/tissue engineering (summarizes evidence for silk proteins in barrier support and regenerative applications). — https://pmc.ncbi.nlm.nih.gov/articles/PMC5124675/

·       Silk fibroin hydrogel + bioactive factor (mouse skin injury model; enhanced wound healing with increased type III collagen and hair follicle formation reported). — https://pubmed.ncbi.nlm.nih.gov/40575657/

·       Review: nicotinamide/niacinamide in skin health (covers acne, inflammation, barrier, and related dermatology uses; useful ingredient-level evidence base for clarifying positioning). — https://www.mdpi.com/1648-9144/61/2/254

·       Review: silk fibroin biomaterials for skin wound healing (overview of mechanisms and preclinical/clinical evidence for silk fibroin in wound repair). — https://www.mdpi.com/2218-273X/12/12/1852

·       Niacinamide reduces hyperpigmentation (clinical) — https://pubmed.ncbi.nlm.nih.gov/12100180/

·       Niacinamide + NAG pigmentation trial — https://pubmed.ncbi.nlm.nih.gov/19845667/

·       Niacinamide aging facial skin (split-face RCT) — https://pubmed.ncbi.nlm.nih.gov/16029679/

·       Niacinamide moisturizer RCT (wrinkles/red blotchiness) — https://pubmed.ncbi.nlm.nih.gov/18492135/

·       Silk sericin moisturizer in vivo — https://pubmed.ncbi.nlm.nih.gov/17168872/

·       Silk fibroin film: randomized controlled clinical trial — https://pubmed.ncbi.nlm.nih.gov/28337854/

·       Silk fibroin bilayer dressing RCT — https://pubmed.ncbi.nlm.nih.gov/26221170/

·       Silk fibroin dressing vs saline RCT — https://pubmed.ncbi.nlm.nih.gov/41415866/

·       Silk surgical site dressing outcomes — https://pubmed.ncbi.nlm.nih.gov/38330504/

·       Silk-based biomaterials in wound healing (review) — https://pubmed.ncbi.nlm.nih.gov/30475285/

·       DMAE facial gel randomized clinical study — https://pubmed.ncbi.nlm.nih.gov/15675889/

·       SCA secretion topical aging study — https://pubmed.ncbi.nlm.nih.gov/30858719/

·       NMN supplementation trial (NAD pathway; systemic) — https://pubmed.ncbi.nlm.nih.gov/36482258/

·       Nicotinamide for photoprotection review (includes RCT references) — https://pubmed.ncbi.nlm.nih.gov/30698874/

·       Tyrosinase inhibitors review (background) — https://pubmed.ncbi.nlm.nih.gov/17605157/

·       Ceramide + magnesium AD (double-blind RCT) — https://pubmed.ncbi.nlm.nih.gov/26939522/

·       Ceramide-dominant cream/cleanser eczema adults — https://pubmed.ncbi.nlm.nih.gov/33984185/

·       Ceramide moisturizer irritation (children AD) — https://pubmed.ncbi.nlm.nih.gov/32372387/

·       Barrier cream cost-efficacy (Atopiclair/EpiCeram/Aquaphor) — https://pubmed.ncbi.nlm.nih.gov/21533301/

·       Ceramide/lipid supplementation improves barrier (free article) — https://pubmed.ncbi.nlm.nih.gov/40408261/

·       Microneedling recovery with ceramide cream (split-face) — https://pubmed.ncbi.nlm.nih.gov/40099382/

·       Ceramides in hand dermatitis program — https://pubmed.ncbi.nlm.nih.gov/36939821/

·       Rhamnosoft + ceramides facial eczema trial — https://pubmed.ncbi.nlm.nih.gov/24750568/

·       Pseudo-ceramide lamellar cream AD — https://pubmed.ncbi.nlm.nih.gov/35852694/

·       Defensil + panthenol + ceramide vs urea in childhood AD — https://pubmed.ncbi.nlm.nih.gov/33865303/

·       Ectoine cream in mild–moderate atopic dermatitis (randomized, intra-individual, double-blind, multi-center trial in 65 patients; ectoine cream was well tolerated and equivalent to a reference barrier-focused comparator). — https://pubmed.ncbi.nlm.nih.gov/23949258/

·       Ectoin antiaging vehicle-controlled RCT — https://pubmed.ncbi.nlm.nih.gov/17519560/

·       Ectoin vs dexpanthenol radiation dermatitis — https://pubmed.ncbi.nlm.nih.gov/37792331/

·       Ectoin use in children/adults (review of studies) — https://pubmed.ncbi.nlm.nih.gov/35038127/

·       Cysteamine vs HQ both with ectoin cream (melasma) — https://pubmed.ncbi.nlm.nih.gov/40127492/