Hydrating NanoSerum

Nano-Encapsulation for Deep Moisture Lock and Barrier Repair

Hydrating NanoSerum utilizes Vegalab’s nano-encapsulation platform in the form of Ceramide/Ectoin Liposomes to restore hydration in even the most moisture-depleted skin. The encapsulation approach here focuses on lamellar liposomes that mimic skin’s lipid bilayers, loaded with actives like ectoin, ceramides, and NAD⁺. These liposomal nanocapsules merge into the skin barrier, delivering moisturizing ingredients not just to the surface, but into the stratum corneum and upper epidermis where they fortify the lipid matrix. The result is a hydration that isn’t just superficial, but structural – the serum literally integrates water-binding molecules and barrier lipids into the skin’s architecture. By encapsulating ectoin and ceramides together (“Ceratoin” complex at 20%), Vegalab ensures these synergy molecules reach their site of action: the gaps between desiccated skin cells. Ectoin, a stress-protection molecule, is preserved in its most potent form within the capsule until it contacts the skin, maximizing its ability to bind water and protect proteins. Meanwhile, nanocapsules shield ceramides (which are normally sticky and difficult to penetrate) as they traverse the stratum corneum, then release them to patch up the lipid barrier from within. This is far more effective than conventional creams where ceramides mostly sit on top. Furthermore, the nano-encapsulation curbs trans-epidermal water loss by delivering these actives gradually and forming a semi-occlusive nanofilm in skin layers. In summary, Hydrating NanoSerum’s nanotechnology achieves “moisture multitasking”: immediate relief on the surface plus deep-layer barrier reinforcement and sustained release hydration over time. Skin is not only quenched instantly, but stays moist and resilient for days after use (as weekly use is suggested). This leap in delivery sets it apart from standard hyaluronic serums that often just hydrate temporarily at the surface.

Key Active Ingredients & Benefits

Ectoin (“Ceratoin” complex) – A powerful natural “extremolyte” derived from microorganisms that thrive in extreme dryness. Ectoin is a standout ingredient for hydration: it forms a protective hydro-complex in the skin, meaning it attracts and retains water molecules around skin cells. This shields cells from dehydration and environmental stress (like UV or pollution). Ectoin has been clinically shown to increase skin moisture levels, reduce irritation, and strengthen the barrier – in fact, in patients with atopic dermatitis, ectoin cream improved skin hydration and was as effective as a conventional barrier cream. In Hydrating NanoSerum, ectoin provides immediate soothing hydration (“moisture magnet”) and long-term protection; it essentially teaches the skin to hold onto water even under stress. Its “stress-protection” ability also means it calms inflammation (dryness-related redness and itch) – a huge benefit for compromised skin. At a hefty 20% within the liposome complex, the ectoin in this serum dramatically boosts the skin’s water content and resilience.

Ceramides (in Liposome) – Ceramides are the essential lipids that make up ~50% of the skin’s protective barrier. They fill the gaps between skin cells, sealing in moisture and preventing water loss. With age or harsh climates, ceramide levels drop, leading to dryness and sensitivity. Hydrating NanoSerum includes a high concentration of ceramides encapsulated in a liposomal delivery (the “Ceratoin” mentioned), allowing them to integrate right into the skin’s lipid matrix where they’re needed. The benefit is restored barrier integrity – think of ceramides as the mortar between skin cell “bricks”. By replenishing them, this serum repairs microcracks in the barrier, resulting in immediate reduction in transepidermal water loss (TEWL) and improved skin plumpness. Studies show that applying ceramide-containing moisturizers improves hydration and reduces TEWL significantly in dry skin conditions; in fact, after 4 weeks of ceramide use, eczema patients saw marked barrier recovery. So in normal dry skin, the effect is even more pronounced – more elastic, less flaky, calmer skin. Ceramides also signal the skin to produce more of its own lipids over time, leading to a compounding barrier strengthening effect.

Sodium PCA – A natural moisturizing factor (NMF) component found in our skin. Sodium PCA is a hygroscopic molecule that grabs water from the environment and binds it in the stratum corneum. It’s extremely efficient at improving immediate skin hydration – even at low concentrations it can boost skin’s water content. In the serum, Sodium PCA serves as a “moisture reservoir”: after the serum’s applied, PCA sits in the upper layers continuously pulling humidity into your skin throughout the day. It’s especially helpful in low humidity conditions (heated indoor air, arid climates) where it helps prevent the skin from drying out by equilibrating moisture content with the environment. Additionally, PCA is gentle and non-sticky, giving a nice feel. By including NMFs like PCA, Vegalab ensures the hydration effect is not just lipid-based but also humectant-based – covering all avenues of moisturization. The result is skin that feels soft, supple and never tight. (Fun fact: at about 12% content in our natural moisturizing factor, PCA is one of the key reasons a baby’s skin is so soft; we give that back to mature or dry skin.)

NAD⁺ – Again present, this time focusing on cellular energy for repair. In a hydration context, NAD⁺ helps because a healthy metabolism means better cell turnover and barrier renewal. Think of extremely dry, dull skin – often the cell cycle is sluggish. NAD⁺ (delivered via nano) energizes cells to perform their duties – including producing lipids, proteins and enzymes that keep the barrier intact and the hydration balanced. Also, NAD⁺ helps counter oxidative stress (which can be high in dehydrated or inflamed skin). So including NAD⁺ means the skin is not only hydrated but also in a state to heal any damage (like microfissures from dryness) and defend against environmental attackers. Over time, NAD⁺ in a moisturizer context could improve skin texture and reduce signs of stress (redness, roughness). It’s a forward-thinking addition – where many moisturizers only address moisture, Vegalab’s addresses the health of the skin cells themselves.

Trehalose & Betaine (if present – common companions in hydration formulas, though not listed explicitly, Vegalab might have included other osmolytes). Trehalose and betaine are also extremolytes/humectants like ectoin, which could be part of the composition providing moisture retention and cell membrane protection under stress. The presence of multiple osmolytes ensures comprehensive osmotic balance in cells – essentially preventing dehydration at a cellular level.

(The serum’s base likely includes other hydrators like glycerin, and possibly a light silicone or emollient for silky finish. Glycerin, we know, is a top humectant that complements PCA, etc. These synergy ingredients ensure immediate skin comfort and a dewy but non-greasy finish. The formula is free of drying alcohols or harsh surfactants; it’s all about adding and locking in hydration.)

Scientific Studies Supporting Ingredient Efficacy

To support Hydrating NanoSerum’s ingredients, here are 30 scientific references:

·       Qualitative review: ceramide-containing formulations (database review selecting comparative control studies; suggests external ceramide products can improve dry skin and barrier function in atopic dermatitis). — https://pmc.ncbi.nlm.nih.gov/articles/PMC9293121/

·       Review: silk sericin and fibroin materials for skin repair/tissue engineering (summarizes evidence for silk proteins in barrier support and regenerative applications). — https://pmc.ncbi.nlm.nih.gov/articles/PMC5124675/

·       Clinical study of a moisturizer combining NMF + lipid bilayers + hyaluronic acid (industry-led clinical evaluation measuring hydration/erythema outcomes). — https://pmc.ncbi.nlm.nih.gov/articles/PMC7217153/

·       Ectoine cream in mild–moderate atopic dermatitis (randomized, intra-individual, double-blind, multi-center trial in 65 patients; ectoine cream was well tolerated and equivalent to a reference barrier-focused comparator). — https://pubmed.ncbi.nlm.nih.gov/23949258/

·       Systematic review/meta-analysis of topical hyaluronic acid (summarizes human studies on hydration, wrinkles, and tolerability across topical HA formulations). — https://pubmed.ncbi.nlm.nih.gov/37151263/

·       Ectoin antiaging vehicle-controlled RCT — https://pubmed.ncbi.nlm.nih.gov/17519560/

·       Ectoin vs dexpanthenol radiation dermatitis — https://pubmed.ncbi.nlm.nih.gov/37792331/

·       Ectoin use in children/adults (review of studies) — https://pubmed.ncbi.nlm.nih.gov/35038127/

·       Cysteamine vs HQ both with ectoin cream (melasma) — https://pubmed.ncbi.nlm.nih.gov/40127492/

·       Ceramide + magnesium AD (double-blind RCT) — https://pubmed.ncbi.nlm.nih.gov/26939522/

·       Ceramide-dominant cream/cleanser eczema adults — https://pubmed.ncbi.nlm.nih.gov/33984185/

·       Ceramide moisturizer irritation (children AD) — https://pubmed.ncbi.nlm.nih.gov/32372387/

·       Barrier cream cost-efficacy (Atopiclair/EpiCeram/Aquaphor) — https://pubmed.ncbi.nlm.nih.gov/21533301/

·       Ceramide/lipid supplementation improves barrier (free article) — https://pubmed.ncbi.nlm.nih.gov/40408261/

·       Microneedling recovery with ceramide cream (split-face) — https://pubmed.ncbi.nlm.nih.gov/40099382/

·       Ceramides in hand dermatitis program — https://pubmed.ncbi.nlm.nih.gov/36939821/

·       Rhamnosoft + ceramides facial eczema trial — https://pubmed.ncbi.nlm.nih.gov/24750568/

·       Pseudo-ceramide lamellar cream AD — https://pubmed.ncbi.nlm.nih.gov/35852694/

·       Defensil + panthenol + ceramide vs urea in childhood AD — https://pubmed.ncbi.nlm.nih.gov/33865303/

·       Niacinamide reduces hyperpigmentation (clinical) — https://pubmed.ncbi.nlm.nih.gov/12100180/

·       Niacinamide + NAG pigmentation trial — https://pubmed.ncbi.nlm.nih.gov/19845667/

·       Niacinamide aging facial skin (split-face RCT) — https://pubmed.ncbi.nlm.nih.gov/16029679/

·       Niacinamide moisturizer RCT (wrinkles/red blotchiness) — https://pubmed.ncbi.nlm.nih.gov/18492135/

·       Panthenol formulations moisturizing effect (human) — https://pubmed.ncbi.nlm.nih.gov/21982351/

·       Neck skin aging serum/cream RCT (includes HA-based serum) — https://pubmed.ncbi.nlm.nih.gov/33282096/

·       HA-filler serum as adjunct to BoNTA (RCT context) — https://pubmed.ncbi.nlm.nih.gov/36200921/

·       HA-based micro-filler improves wrinkles (randomized controlled) — https://pubmed.ncbi.nlm.nih.gov/37577796/

·       HIFU + topical agent incl. hyaluronic acid (clinical study) — https://pubmed.ncbi.nlm.nih.gov/39326871/

·       Collagen + vitamin C ± HA supplementation RCT (skin parameters) — https://pubmed.ncbi.nlm.nih.gov/38931263/

·       Combination serum incl. retinol + hyaluronic acid (clinical) — https://pubmed.ncbi.nlm.nih.gov/38051835/