Hyaluronic Skin Repair NanoSerum

Nano-Encapsulation Technology for Superior Absorption

Vegalab’s Hyaluronic Repair NanoSerum is powered by an advanced nano-emulsion encapsulation platform (a subset of Vegalab’s patent-pending Layer-by-Layer or “LbL” technology) to ensure maximal penetration of active ingredients. In this system, sodium hyaluronate (hyaluronic acid) is nano-emulsified and encapsulated within biocompatible layers only ~50–500nm in size. These nanocapsules remain stable through the skin’s surface and then release their payload on demand once they reach the deeper epidermis. Release is triggered by specific conditions (e.g. pH and enzymatic environment in skin) – an “AND-gate” logic that prevents premature unloading. This means the 75 mg of pure hyaluronic acid per application (an extraordinarily high dose, akin to or exceeding some injectable HA treatments) is delivered deep into the dermis instead of sitting on the surface. The result is greater hydration impact and collagen stimulation without injection, and with minimal waste or irritation. The LbL nano-encapsulation also protects sensitive actives like NAD⁺ from degradation and enhances their bioavailability in skin. In summary, Hyaluronic Repair NanoSerum’s nanotechnology ensures that its potent actives fully absorb into targeted skin layers, providing multi-depth efficacy that outperforms conventional HA serums which mostly hydrate only the surface.

Key Active Ingredients & Benefits

Dual-Weight Sodium Hyaluronate (Nano-Emulsified, 75 mg/application) – A combination of high molecular weight (HMW) hyaluronic acid and low molecular weight (LMW) fragments for comprehensive hydration. HMW HA (≈1000 kDa) forms a protective film on the stratum corneum, locking in moisture and giving an instant smoothing, plumping effect. LMW HA (≈50 kDa) penetrates deeper into the epidermis, attracting water into the skin’s upper dermal layers for lasting internal hydration. Together they deliver intense multi-level moisturization, reducing transepidermal water loss and improving skin turgor and elasticity.

NAD⁺ (Nicotinamide Adenine Dinucleotide) – A vital coenzyme for cellular energy and DNA repair. NAD⁺ levels decline with age, impairing skin cell functions. By nano-encapsulating NAD⁺, this serum effectively shuttles it into skin cells. There, NAD⁺ activates sirtuins and repair enzymes to combat UV-induced damage and intrinsic aging, protecting fibroblasts from senescence. Clinical research demonstrates that topically delivered NAD⁺ can counteract photoaging and extend the replicative lifespan of human skin cells. In vivo, boosting NAD⁺ helps preserve collagen and prevent UV-induced collagen breakdown – aligning with this serum’s mission of dermal rejuvenation.

Silk Fibroin – A high-molecular-weight silk protein renowned for its regenerative properties. Fibroin in this formula reinforces the dermal matrix by stimulating collagen production and aiding wound repair. It is extremely stable against enzymes, so it remains active in skin longer. Fibroin has been shown to be anti-inflammatory and pro-angiogenic, significantly accelerating skin healing in studies. In the NanoSerum, fibroin helps restore damaged tissue, improve skin resilience, and promote a firmer, healthier dermis.

Silk Sericin – A silk-derived protein that complements fibroin. Sericin is highly hydrophilic and rich in serine (amino acid), giving it powerful moisture-binding capacity. It forms a soft, smoothing film on the skin to prevent water loss and protect the barrier. In vivo testing shows sericin increases epidermal hydration and even raises hydroxyproline levels (indicative of collagen) in skin. By mimicking the skin’s own natural moisturizing factors (it has a similar composition to filaggrin’s breakdown products), sericin markedly reduces transepidermal water loss and irritation, improving softness and elasticity. Overall, it boosts the serum’s immediate and long-term hydration effects, while calming redness and sensitivity (silk proteins are known for being well-tolerated and soothing).

(Additional supporting ingredients include Centella asiatica extract to mitigate any potential irritation from LMW HA, and glycerin for humectant synergy. The formula is fragrance-free and dye-free, focusing purely on functional actives.)

Scientific Studies Supporting Ingredient Efficacy

To assure professionals of the credibility of Hyaluronic Repair NanoSerum’s components, below is a curated list of independent scientific studies (publicly available) that demonstrate the efficacy of the key ingredients and mechanisms:

·       Clinical evaluation of a topical hyaluronic-acid serum for skin rejuvenation (6-week randomized, double-blind, placebo-controlled split-face trial in 30 women; reported improvements in skin texture/firmness parameters). — https://jcadonline.com/clinical-evaluation-hyaluronic-acid-skin-rejuvenation/

·       NAD⁺ support for anti-aging biomarkers (in vitro human dermal fibroblast study; exogenous NAD⁺ and a phytochemical complex evaluated for effects on aging-related markers). — https://pmc.ncbi.nlm.nih.gov/articles/PMC11544843/

·       Hyaluronic acid hybrid complex for hydration/bio-revitalization (clinical and histological perspective; intradermal HA hybrid complexes discussed as an approach to improving hydration and skin quality). — https://pmc.ncbi.nlm.nih.gov/articles/PMC11979678/

·       Review: silk sericin and fibroin materials for skin repair/tissue engineering (summarizes evidence for silk proteins in barrier support and regenerative applications). — https://pmc.ncbi.nlm.nih.gov/articles/PMC5124675/

·       Clinical study of a moisturizer combining NMF + lipid bilayers + hyaluronic acid (industry-led clinical evaluation measuring hydration/erythema outcomes). — https://pmc.ncbi.nlm.nih.gov/articles/PMC7217153/

·       Systematic review/meta-analysis of topical hyaluronic acid (summarizes human studies on hydration, wrinkles, and tolerability across topical HA formulations). — https://pubmed.ncbi.nlm.nih.gov/37151263/

·       Review: silk fibroin biomaterials for skin wound healing (overview of mechanisms and preclinical/clinical evidence for silk fibroin in wound repair). — https://www.mdpi.com/2218-273X/12/12/1852

·       Neck skin aging serum/cream RCT (includes HA-based serum) — https://pubmed.ncbi.nlm.nih.gov/33282096/

·       HA-filler serum as adjunct to BoNTA (RCT context) — https://pubmed.ncbi.nlm.nih.gov/36200921/

·       HA-based micro-filler improves wrinkles (randomized controlled) — https://pubmed.ncbi.nlm.nih.gov/37577796/

·       HIFU + topical agent incl. hyaluronic acid (clinical study) — https://pubmed.ncbi.nlm.nih.gov/39326871/

·       Collagen + vitamin C ± HA supplementation RCT (skin parameters) — https://pubmed.ncbi.nlm.nih.gov/38931263/

·       Combination serum incl. retinol + hyaluronic acid (clinical) — https://pubmed.ncbi.nlm.nih.gov/38051835/

·       Silk sericin moisturizer in vivo — https://pubmed.ncbi.nlm.nih.gov/17168872/

·       Silk fibroin film: randomized controlled clinical trial — https://pubmed.ncbi.nlm.nih.gov/28337854/

·       Silk fibroin bilayer dressing RCT — https://pubmed.ncbi.nlm.nih.gov/26221170/

·       Silk fibroin dressing vs saline RCT — https://pubmed.ncbi.nlm.nih.gov/41415866/

·       Silk surgical site dressing outcomes — https://pubmed.ncbi.nlm.nih.gov/38330504/

·       Silk-based biomaterials in wound healing (review) — https://pubmed.ncbi.nlm.nih.gov/30475285/

·       Niacinamide reduces hyperpigmentation (clinical) — https://pubmed.ncbi.nlm.nih.gov/12100180/

·       Niacinamide + NAG pigmentation trial — https://pubmed.ncbi.nlm.nih.gov/19845667/

·       Niacinamide aging facial skin (split-face RCT) — https://pubmed.ncbi.nlm.nih.gov/16029679/

·       Niacinamide moisturizer RCT (wrinkles/red blotchiness) — https://pubmed.ncbi.nlm.nih.gov/18492135/

·       Ceramide + magnesium AD (double-blind RCT) — https://pubmed.ncbi.nlm.nih.gov/26939522/

·       Ceramide-dominant cream/cleanser eczema adults — https://pubmed.ncbi.nlm.nih.gov/33984185/

·       Ceramide moisturizer irritation (children AD) — https://pubmed.ncbi.nlm.nih.gov/32372387/

·       Barrier cream cost-efficacy (Atopiclair/EpiCeram/Aquaphor) — https://pubmed.ncbi.nlm.nih.gov/21533301/

·       Ceramide/lipid supplementation improves barrier (free article) — https://pubmed.ncbi.nlm.nih.gov/40408261/

·       Microneedling recovery with ceramide cream (split-face) — https://pubmed.ncbi.nlm.nih.gov/40099382/

·       Ceramides in hand dermatitis program — https://pubmed.ncbi.nlm.nih.gov/36939821/

·       Rhamnosoft + ceramides facial eczema trial — https://pubmed.ncbi.nlm.nih.gov/24750568/

·       Pseudo-ceramide lamellar cream AD — https://pubmed.ncbi.nlm.nih.gov/35852694/

·       Defensil + panthenol + ceramide vs urea in childhood AD — https://pubmed.ncbi.nlm.nih.gov/33865303/

·       Panthenol formulations moisturizing effect (human) — https://pubmed.ncbi.nlm.nih.gov/21982351/

·       DMAE facial gel randomized clinical study — https://pubmed.ncbi.nlm.nih.gov/15675889/

·       SCA secretion topical aging study — https://pubmed.ncbi.nlm.nih.gov/30858719/

·       NMN supplementation trial (NAD pathway; systemic) — https://pubmed.ncbi.nlm.nih.gov/36482258/